Related Experiment Video

Updated: Apr 20, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

8.1K

The differential expression of microRNA-143,145 in endometriosis

Bingbing Zheng1, Xiangyang Xue2, Yiping Zhao3

  • 1Department of Obstetrics, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.

Iranian Journal of Reproductive Medicine
|November 20, 2014
PubMed
Abstract

Insights

MicroRNAs (miRNAs) miR-143 and miR-145 are upregulated in endometriosis tissues. These findings suggest that these miRNAs may contribute to the development and progression of endometriosis.

Area of Science:

  • Reproductive biology
  • Molecular biology
  • Oncology

Background:

  • MicroRNA (miRNA) dysregulation is linked to human tumor development.
  • Understanding miRNA alterations in endometriosis is crucial.

Purpose of the Study:

  • To investigate the expression levels of miR-143 and miR-145 in women with endometriosis.
  • To determine the role of these miRNAs in the pathogenesis of endometriosis.

Main Methods:

  • Real-time RT-PCR was employed to quantify miR-143 and miR-145 expression.
  • Samples included eutopic endometrium (EU) and ectopic endometrium (EC) from women with endometriosis, and normal endometrium (EN) from controls.

Main Results:

  • miR-143 and miR-145 expression did not vary with the menstrual cycle in normal or ectopic tissues.
  • Both miR-143 and miR-145 were significantly upregulated in ectopic endometrium compared to normal endometrium.
  • miR-143 and miR-145 were also upregulated in eutopic endometrium compared to normal endometrium, with miR-145 showing statistical significance.

Conclusions:

  • The study indicates that miR-143 and miR-145 are differentially expressed in endometriosis.
  • These microRNAs may play a significant role in the development and progression of endometriosis.
Keywords:
EndometriosisMiR-143MiR-145MiRNA (microRNA)

More Related Videos

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.1K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
25.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.4K