Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

4.4K
Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
4.4K
Nondisjunction01:21

Nondisjunction

6.0K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
6.0K
Nondisjunction01:29

Nondisjunction

84.3K
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
84.3K
Nondisjunction01:29

Nondisjunction

10.3K
10.3K
Teratogenicity01:07

Teratogenicity

4.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.6K
Pleiotropy01:33

Pleiotropy

44.4K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
44.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of hirsutism in Turkey: Data of the dermatoendocrinology study group.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Evaluation of Social Anxiety Levels and Related Factors in Psoriasis Patients: A Controlled, Cross-Sectional Study.

Noro psikiyatri arsivi·2020
Same author

Platelet Count and Mean Platelet Volume in Psoriasis Patients.

Sisli Etfal Hastanesi tip bulteni·2020
Same author

Social Appearance Anxiety in Adult Patients with Acne: A Cross-Sectional Study.

Acta dermatovenerologica Croatica : ADC·2018
Same author

Epidemiology of Pemphigus in Turkey: One-year Prospective Study of 220 Cases.

Acta dermatovenerologica Croatica : ADC·2017
Same author

LATE-ONSET SELF-HEALING LANGERHANS CELL HISTIOCYTOSIS: REPORT OF A VERY RARE ENTITY.

Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo·2017

Related Experiment Video

Updated: Apr 20, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.2K

Total congenital anonychia.

Fatma Sule Afsar1, Ali Karakuzu

  • 1Department of Dermatology, Ataturk Research and Training Hospital, Izmir, Turkey.

Pediatric Dermatology
|November 27, 2014
PubMed
Summary

Congenital anonychia, the absence of nails at birth, is a rare condition. This case highlights a boy with total anonychia, whose parents were related, suggesting a potential genetic link.

Area of Science:

  • Genetics
  • Dermatology
  • Pediatrics

Background:

  • Nail development is a complex process.
  • Congenital anonychia is a rare disorder affecting nail formation.
  • Inheritance patterns can be autosomal dominant or recessive.

Observation:

  • A 4-year-old boy presented with total congenital anonychia.
  • The patient was otherwise healthy.
  • His parents were first-degree relatives, indicating consanguinity.

Findings:

  • The diagnosis of total congenital anonychia was confirmed.
  • The consanguineous parentage in this case warrants further investigation into recessive inheritance patterns.
  • This presentation is unusual given the rarity of the condition.

More Related Videos

A Mouse Model of Ankle-Subtalar Complex Joint Instability
09:14

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

2.0K
Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
09:52

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

27.9K

Related Experiment Videos

Last Updated: Apr 20, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.2K
A Mouse Model of Ankle-Subtalar Complex Joint Instability
09:14

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

2.0K
Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
09:52

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

27.9K

Implications:

  • Understanding the genetic basis of anonychia is crucial for genetic counseling.
  • Further research is needed to identify specific genes involved in autosomal recessive anonychia.
  • This case contributes to the literature on rare genetic dermatological conditions in children.