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Updated: Apr 20, 2026

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications
Published on: June 16, 2023
Hypoplastic left heart syndrome - unresolved issues
Raoul Roman Arnold1, Tsvetomir Loukanov2, Matthias Gorenflo1
1Clinic for Paediatric and Congenital Cardiac Cardiology, University Medical Centre , Heidelberg , Germany.
Abstract:
Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart defects. At present, it is expected that - at best - 70% of newborns with HLHS will reach adulthood. This review addresses the problems of right ventricular (RV) failure and insufficient growth of pulmonary vasculature in these patients. In order to further improve long-term prognosis translational research to control RV function, growth of pulmonary arteries and progress in chronic circulatory support are clearly needed to provide a further improvement for adults with HLHS.
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