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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Prognostic impact of the TP53 rs1625895 polymorphism in DLBCL patients
Elena N Voropaeva1, Mikhail I Voevoda, Tatiana I Pospelova
1Institute of Internal and Preventive Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russia.
Abstract:
This study aimed to clarify the association between the TP53 rs1625895 polymorphism and the efficiency of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) therapy in 106 patients with diffuse large B cell lymphoma (DLBCL). All patients received six to eight courses of R-CHOP therapy as a first-line treatment. The rs1625895 polymorphism was genotyped by polymerase chain reaction with restriction fragment length polymorphism assay. The G/G genotype of the TP53 rs1625895 polymorphism was shown to be associated with a high probability of R-CHOP therapy failure in DLBCL patients according to the probability of remission as well as 5-year overall and relapse-free survivals.
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