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Changes in immunity parameters and blood cytokine concentrations after chronic nitrile acrylate intoxication
P F Zabrodskii1, M S Gromov, V V Maslyakov
1Saratov Affiliated Department of REAVIZ Samara Medical Institute, Saratov, Russia, pfzabrodsky@gmail.com.
Abstract:
Experiments on outbred albino rats showed that chronic nitrile acrylate intoxication (60 days, 0.05 LD50 per day subcutaneously) led to reduction of T-dependent humoral immune response (T-independent humoral immune response was less affected); parameters cell immunity were suppressed to a greater extent than parameters of humoral immune reactions. Equal attenuation of the functions of Th1 and Th2 lymphocytes, decrease of the blood levels of immunoregulatory, pro- and anti-inflammatory cytokines (IFN-γ, IL-2, IL-4, IL-6, IL-10, IL-13), and decrease of acetyl cholinesterase activity in thymic and splenic T lymphocytes were observed.
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