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Related Concept Videos

Portal Hypertension01:22

Portal Hypertension

19
Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
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Hepatic Encephalopathy01:29

Hepatic Encephalopathy

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DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic...
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Hepatic Portal System01:21

Hepatic Portal System

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
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Related Experiment Video

Updated: Apr 20, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
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Transjugular intrahepatic portosystemic shunt.

Kavish R Patidar1, Malcolm Sydnor2, Arun J Sanyal3

  • 1Department of Internal Medicine, Virginia Commonwealth University Hospital, 1200 East Broad Street, MCV Box 980342, Richmond, VA 23298-0342, USA.

Clinics in Liver Disease
|December 2, 2014
PubMed
Summary

Transjugular intrahepatic portosystemic shunt (TIPS) improves outcomes for portal hypertension complications like bleeding and ascites. Enhanced stent technology has boosted shunt patency, necessitating a review of TIPS utility and techniques.

Keywords:
AscitesBudd-Chiari syndromeEsophageal varicesHepatic hydrothoraxHepatopulmonary syndromeHepatorenal syndromeTransjugular intrahepatic portosystemic shuntVenoocclusive disease

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Area of Science:

  • Hepatology
  • Interventional Radiology
  • Gastroenterology

Background:

  • Portal hypertension complications significantly impact patient outcomes.
  • Transjugular intrahepatic portosystemic shunt (TIPS) is a key intervention for managing these complications.
  • Evidence supports TIPS for variceal bleeding and ascites, with consideration for other conditions.

Purpose of the Study:

  • To reassess the utility of Transjugular intrahepatic portosystemic shunt (TIPS).
  • To review the management of complications associated with TIPS.
  • To enhance understanding of various TIPS techniques and their impact on outcomes.

Main Methods:

  • Review of existing literature and clinical evidence on TIPS procedures.
  • Analysis of outcomes associated with different stent types, particularly polytetrafluoroethylene-covered stents.
  • Evaluation of indications and contraindications for TIPS.

Main Results:

  • Polytetrafluoroethylene-covered stents have significantly improved shunt patency compared to bare metal stents.
  • Improved shunt patency correlates with better patient outcomes.
  • TIPS remains a critical procedure for specific, severe complications of portal hypertension.

Conclusions:

  • The advancement in stent technology has revitalized the role of TIPS.
  • A comprehensive understanding of TIPS techniques and complication management is crucial for optimizing patient care.
  • Further evaluation of TIPS utility in diverse clinical scenarios is warranted.