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[Stimuli-sensitive polymer systems].

D Le Cerf1

  • 1Normandie université, France; Laboratoire polymères biopolymères surfaces, université de Rouen, 76821 Mont Saint-Aignan, France; CNRS UMR 6270 & FR3038, 76821 Mont Saint-Aignan, France.

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Summary
This summary is machine-generated.

Smart polymers change in response to external stimuli like temperature or pH, enabling controlled release of active substances in biomedical applications. This review explores stimuli-responsive polymers and their controlled release mechanisms.

Keywords:
Champ magnétiqueLightLumièreMagnetic fieldPolymerPolymèreStimuliStimulusTemperatureTempératurepH

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Polymers exist in various forms (particles, capsules, hydrogels) with broad applications.
  • Stimuli-sensitive polymers, or smart polymers, undergo physical/chemical changes in response to external signals.
  • These polymers are promising for entrapping and delivering active substances, but controlling release remains a challenge.

Purpose of the Study:

  • To review stimuli-responsive polymers and their theoretical aspects.
  • To discuss polymers that respond to various physical and chemical stimuli.
  • To illustrate systems for controlled release of active compounds using stimuli-sensitive pathways.

Main Methods:

  • Classification of stimuli into physical (temperature, light, fields) and chemical/biochemical (pH, enzymes, molecules).
  • Discussion of polymer chain conformation and solvation changes induced by stimuli.
  • Review of literature examples demonstrating stimuli-triggered release.

Main Results:

  • Stimuli-sensitive polymers offer tunable responses for active compound delivery.
  • External stimuli (temperature, light, fields) and internal stimuli (pH, enzymes) can trigger polymer changes.
  • Various polymer architectures and stimuli-responsive mechanisms are detailed.

Conclusions:

  • Stimuli-responsive polymers are key for advanced drug delivery systems.
  • Understanding stimuli-polymer interactions is crucial for designing effective controlled-release formulations.
  • This review provides a foundation for developing novel smart polymer-based therapeutic agents.