Related Experiment Video
Updated: Apr 20, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Obesity-related kidney disease
Samuel Snyder1, Gracie A Turner2, Alan Turner3
1Nova Southeastern University, 3200 S. University Drive, Fort Lauderdale, FL 33328, USA.
Abstract:
The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.
Related Concept Videos
External Anatomy of the Kidney
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Diabetic Nephropathy
Drug Dosing: Obese Patients
Chronic Kidney Disease I: Introduction
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Obesity

