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Hepatic artery infusion chemotherapy for liver malignancy
Julie N Leal1, T Peter Kingham1
1Department of Surgery, Division of Hepatopancreatobiliary Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Surgical Oncology Clinics of North America
|December 3, 2014
Summary
Hepatic artery infusion (HAI) chemotherapy is mainly studied for colorectal cancer liver metastases. This review examines HAI methods, complications, and outcomes for primary liver cancers and other liver metastases.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Hepatic artery infusion (HAI) chemotherapy is predominantly researched for colorectal cancer liver metastases (CRLM).
- Limited North American research exists on HAI chemotherapy for primary liver cancers (PLC) or noncolorectal liver metastases (non-CRLM).
- Controversy persists regarding the optimal use of HAI chemotherapy despite extensive evaluation.
Purpose of the Study:
- To review the methods of HAI chemotherapy delivery.
- To discuss technical aspects of catheter and pump insertion for HAI chemotherapy.
- To evaluate outcomes of clinical trials and reviews concerning HAI chemotherapy in CRLM, PLC, and non-CRLM settings.
Main Methods:
- Review of existing clinical trials and literature on HAI chemotherapy.
- Discussion of technical procedures for HAI catheter and pump placement.
- Analysis of complications associated with HAI chemotherapy delivery.
Main Results:
- The article details methods for HAI chemotherapy delivery and device insertion.
- It addresses specific complications related to HAI chemotherapy.
- Outcomes from trials involving CRLM, PLC, and non-CRLM are evaluated.
Conclusions:
- HAI chemotherapy delivery methods and technical aspects are elucidated.
- Complications and outcomes of HAI chemotherapy across different liver cancer types are assessed.
- This review provides a comprehensive overview of HAI chemotherapy for various liver malignancies.
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