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Rapid T2- and susceptometry-based CMRO2 quantification with interleaved TRUST (iTRUST).

Zachary B Rodgers1, Erin K Englund1, Michael C Langham1

  • 1Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA.

Neuroimage
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

A new interleaved TRUST (iTRUST) method enables rapid, simultaneous brain oxygen metabolism (CMRO2) quantification using both susceptometry and T2-based techniques. This approach improves temporal resolution and reveals potential biases between measurement methods.

Keywords:
Blood oxygen saturationCMRO(2)HypercapniaMR susceptometryPhase-contrast MRITRUST

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Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Cerebral metabolic rate of oxygen (CMRO2) is vital for assessing brain function.
  • Susceptometry-based oximetry (SBO) and T2-relaxation-under-spin-tagging (TRUST) are established methods for CMRO2 quantification.
  • Existing methods often require separate measurements for blood flow and venous oxygen saturation (Yv).

Purpose of the Study:

  • To introduce and validate the interleaved TRUST (iTRUST) method for simultaneous CMRO2 quantification.
  • To enable direct comparison between SBO- and TRUST-derived Yv values.
  • To improve the temporal resolution of CMRO2 measurements.

Main Methods:

  • Developed iTRUST by integrating a flow-encoded, dual-echo gradient-recalled echo (OxFlow) module into the TRUST sequence.
  • Compared iTRUST to standalone TRUST and OxFlow in resting subjects at baseline.
  • Applied iTRUST to 10 healthy subjects during a 5% CO2 breathing challenge.

Main Results:

  • iTRUST demonstrated close agreement and comparable precision with separate SBO and TRUST techniques at baseline.
  • Simulations and baseline data support using two T2 preparation times for efficient Yv and CMRO2 quantification.
  • During hypercapnia, T2-based CMRO2 showed a significant decrease (-14.6%), while susceptometry-based CMRO2 remained unchanged, indicating a systematic bias between methods.

Conclusions:

  • iTRUST provides rapid, simultaneous SBO- and T2-based CMRO2 quantification with improved temporal resolution.
  • The study confirms the reliability of iTRUST while highlighting a systematic bias between susceptometry- and T2-based Yv quantification.
  • iTRUST offers a valuable tool for neuroimaging research and clinical applications requiring precise brain oxygen metabolism assessment.