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Updated: Apr 20, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
Published on: March 18, 2014
Association between P-glycoprotein expression and response to chemotherapy in patients with osteosarcoma: a
Zhi-Gang Zhao1, Fan Ding, Ming Liu
1Department of Orthopedics, Orthopedics Hospital of Wuhan, Wuhan 430033, China.
Objective:
The aim was to investigate the association between p-glycoprotein (Pgp) expression and response to chemotherapy in patients with osteosarcoma.
Materials And Methods:
We searched and included the openly published articles evaluated the correlation between Pgp expression and response to chemotherapy. The odds ratio (OR) of response rate for Pgp positive group versus Pgp negative group was aggregated by random or fixed effect model.
Results:
Twelve studies were included in our meta-analysis. The mean Pgp positive rate was 0.39 ± 0.10 with its range of (0.14-0.53). The summary response rate was 0.46 ± 0.16 in Pgp positive and 0.57 ± 0.27 in the Pgp negative group, with no statistical difference between two groups (P > 0.05). The pooled OR of response rate for Pgp positive group versus Pgp negative group was 0.75 with its 95% confidence interval of 0.47-1.22, indicating there was no association between Pgp expression and response to chemotherapy in patients with osteosarcoma.
Conclusion:
The present evidence indicated that there was no association between p-glycoprotein expression and chemotherapy response in patients with osteosarcoma.
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