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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
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Herpes simplex virus infection during pregnancy.

Alyssa Stephenson-Famy1, Carolyn Gardella2

  • 1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA.

Obstetrics and Gynecology Clinics of North America
|December 3, 2014
PubMed
Summary

Genital herpes during pregnancy, particularly from herpes simplex virus type 1 (HSV-1), poses risks to newborns. Current prevention strategies are limited, highlighting the need for better interventions against HSV infections in pregnant individuals.

Keywords:
Antiviral therapyGenital herpesNeonatal herpesPregnancyPreventionSerologic screening

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Neonatal Health

Background:

  • Genital herpes during pregnancy contributes to maternal morbidity.
  • Herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital herpes cases via oral-labial transmission.
  • Neonatal herpes, a severe condition for newborns, is most likely following primary maternal infections with HSV-1 or HSV-2 near delivery.

Purpose of the Study:

  • To highlight the growing concern of genital herpes in pregnancy due to HSV-1.
  • To underscore the risks associated with primary HSV infections in late pregnancy.
  • To identify limitations in current prevention and diagnostic approaches for genital herpes in pregnant individuals.

Main Methods:

  • Review of current literature on genital herpes in pregnancy.
  • Analysis of transmission dynamics of HSV-1 and HSV-2.
  • Evaluation of the efficacy of existing prevention and serologic testing strategies.

Main Results:

  • Increasing prevalence of genital herpes in pregnancy attributed to HSV-1.
  • Primary HSV infections near term present the highest risk for neonatal herpes transmission.
  • Lack of effective interventions for primary infection prevention and uncertainty regarding routine serologic testing hinder control efforts.

Conclusions:

  • Genital herpes in pregnancy remains a significant concern, with a notable rise in HSV-1 cases.
  • Effective strategies are needed to prevent primary HSV infections in pregnant individuals.
  • Further research is required to clarify the role of serologic testing in managing genital herpes during pregnancy to prevent neonatal complications.