Related Experiment Video
Updated: Apr 20, 2026
08:39
Author Spotlight: Polysome Profiling Protocol for Studying Translational Regulation in Arabidopsis Under Heat Stress
Published on: October 11, 2024
2.4K
Cooling in a low-resource environment: lost in translation
Paolo Montaldo1, Shreela S Pauliah1, Peter J Lally1
1Centre for Perinatal Neuroscience, Imperial College London, Hammersmith Hospital, London, UK.
Seminars in Fetal & Neonatal Medicine
|December 3, 2014
Summary
Cooling therapy for neonatal encephalopathy (NE) is standard in high-income nations but not in low- and middle-income countries (LMIC). Barriers include cost, intensive care needs, and lack of trials, hindering NE treatment globally.
Area of Science:
- Neonatal Medicine
- Global Health Equity
Background:
- Therapeutic hypothermia is a standard NE treatment in high-income countries.
- Neonatal encephalopathy (NE) disproportionately affects low- and middle-income countries (LMIC).
- Cooling therapy is underutilized in LMIC despite NE's high burden.
Purpose of the Study:
- To identify major barriers to implementing cooling therapy for NE in LMIC.
- To assess the feasibility and safety of cooling therapy in LMIC settings.
- To highlight the need for further research and clinical trials in LMIC.
Main Methods:
- Review of existing literature on NE treatment in LMIC.
- Analysis of factors hindering cooling therapy adoption.
- Examination of emerging data from LMIC regarding cooling therapy.
Main Results:
- Key barriers include population comorbidities, suboptimal intensive care, and lack of affordable cooling devices.
- Emerging data suggest cooling is feasible without tertiary intensive care.
- Limited data exist on the safety and efficacy of cooling in LMIC populations.
Conclusions:
- Addressing barriers is crucial for equitable access to NE cooling therapy.
- Further adequately powered clinical trials are essential to establish safety and efficacy in LMIC.
- Widespread adoption of cooling therapy in LMIC requires robust evidence and accessible technology.
Keywords:
Low- and middle-income countriesNeonatal encephalopathyNeonatal mortalityTherapeutic hypothermiaMore Related Videos
Related Concept Videos
01:09Thermal Stress
3.7K
If the temperature of an object is changed while it is prevented from expanding or contracting, the object is subjected to stress. The stress is compressive if the object expands in the absence of constraint and tensile if it contracts. This stress resulting from temperature change is known as thermal stress. It can be quite large and can cause damage. To avoid this stress, engineers may design components so they can expand and contract freely. For instance, on highways, gaps are deliberately...
3.7K
01:27Thermal expansion and Thermal stress: Problem Solving
2.5K
San Francisco's Golden Gate Bridge is exposed to temperatures ranging from -15 °C to 40 °C. At its coldest, the main span of the bridge is 1275 m long. Assuming that the bridge is made entirely of steel, what is the change in its length between these temperatures?
To solve the problem, first, identify the known and unknown quantities. The initial length (L) of the bridge is 1275 m, the coefficient of linear expansion (α) for steel is 12 x 10-6/°C, and the change in temperature (ΔT) is 55...
To solve the problem, first, identify the known and unknown quantities. The initial length (L) of the bridge is 1275 m, the coefficient of linear expansion (α) for steel is 12 x 10-6/°C, and the change in temperature (ΔT) is 55...
2.5K
01:29Decreased Body Temperature
1.2K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.2K
02:45Responses to Heat and Cold Stress
15.9K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
15.9K
01:21Barriers to Effective Communication II
5.8K
The barriers to effective communication also include cultural barriers, semantic barriers, gender barriers, and time constraints.
Cultural barriers:
Differences in values, beliefs, religion, knowledge, and tradition can significantly impact communication. Awareness of nonverbal cues is critical, especially when conversing with a patient from a different culture. What appears appropriate in one culture may be inappropriate in another.
Semantic barriers:
As a result of their tendency to use...
Cultural barriers:
Differences in values, beliefs, religion, knowledge, and tradition can significantly impact communication. Awareness of nonverbal cues is critical, especially when conversing with a patient from a different culture. What appears appropriate in one culture may be inappropriate in another.
Semantic barriers:
As a result of their tendency to use...
5.8K
01:19Mechanism of heat transfer
2.4K
Understanding heat transfer mechanisms is essential for understanding how our bodies maintain balance in different environmental conditions. When the environment is thermoneutral, the body is in a state of balance, neither using nor releasing energy to maintain its core temperature. However, when the environment is not thermoneutral, the body employs four heat transfer mechanisms to maintain homeostasis: conduction, convection, evaporation, and radiation. These mechanisms facilitate heat...
2.4K