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Updated: Apr 20, 2026
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Initial operative treatment of isolated ileal Crohn's disease in adolescents
Ann M Kulungowski1, Shannon N Acker1, Edward J Hoffenberg2
1Department of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Avenue, Aurora, CO 80045, USA; Division of Surgery, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
Insights
Surgical resection of isolated ileal Crohn's disease (CD) in children improves symptoms and reduces medication needs. This intervention also supports significant catch-up growth in weight and body mass index post-surgery.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Inflammatory Bowel Disease Research
Background:
- Crohn's disease (CD) in children can present as localized disease.
- The impact of surgical intervention on growth and medication needs in pediatric CD is an area of ongoing research.
Purpose of the Study:
- To evaluate the efficacy of surgical resection for single-site pediatric Crohn's disease.
- To assess changes in clinical status, medication requirements, and growth parameters following ileocecetomy.
Main Methods:
- Retrospective review of pediatric patients with isolated ileal CD who underwent ileocecetomy.
- Data collected on clinical improvement, medication adjustments, weight, BMI, and height percentiles.
Main Results:
- Ileocecetomy led to clinical improvement in 84.6% of patients.
- 65.4% of patients decreased medication requirements post-surgery.
- Significant increases in weight and BMI percentiles were observed at 1 and 3 years, with height showing improvement at 3 years.
Conclusions:
- Surgical resection of isolated ileal segments in pediatric Crohn's disease promotes catch-up growth.
- Resection effectively reduces medication requirements and improves clinical outcomes in affected children.
Background:
We hypothesize that in children with Crohn's disease (CD) isolated to a single site, resection leads to clinical improvement, decreased medication requirements, and improved growth.
Methods:
A retrospective review was conducted of children with CD isolated to the terminal ileum undergoing operative intervention at Children's Hospital Colorado between 2002 and 2013.
Results:
Twenty-six patients underwent ileocecetomy (mean age at diagnosis 14.1 ± 2.6 years; mean age at resection 15.7 ± 2.5 years; median follow-up 2 ± 1.5 years). Twenty-two (84.6%) patients reported clinical improvement and 17 (65.4%) were able to decrease the number or dosage of medications. Average weight increased from the 29th to the 45th percentile (P = .09) at 1 year and to the 56th percentile (P = .02) at 3 years post resection. Average body mass index increased from the 30th to the 48th and 49th percentile at 1 and 3 years (P < .05 for both), respectively. Height increased from the 39th percentile at the time of resection to the 51st percentile at 3 years (P = nonsignificant).
Conclusion:
Surgical resection of an isolated ileal segment in adolescents with CD allows for catch-up growth and reduction in medication requirements.
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