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Published on: October 21, 2014
Structural insights into the architecture of the hyperthermophilic Fusellovirus SSV1
Kenneth M Stedman1, Melissa DeYoung1, Mitul Saha2
1Center for Life in Extreme Environments, Biology Department, Portland State University, Portland, OR, USA.
Abstract:
The structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the first 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.
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