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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

16
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
16
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.6K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.6K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

21
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
21
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

17
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
17
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

948
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
948
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.2K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.2K

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Management of Acute Pancreatitis.

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American College of Gastroenterology Guidelines: Management of Acute Pancreatitis.

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Drug-Induced Acute Pancreatitis: An Evidence-Based Classification (Revised).

Clinical and translational gastroenterology·2023
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Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis.

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Recurrent Acute Pancreatitis: International State-of-the-Science Conference With Recommendations.

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Related Experiment Video

Updated: Apr 20, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

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Drug induced acute pancreatitis: does it exist?

Scott Tenner1

  • 1Scott Tenner, Division of Gastroenterology, Department of Medicine, State University of New York, Brooklyn, NY 11235, United States.

World Journal of Gastroenterology
|December 4, 2014
PubMed
Summary

Drug-induced acute pancreatitis is rare, despite numerous case reports. Overdiagnosis leads to misconceptions and inappropriate patient care, hindering the identification of true idiopathic acute pancreatitis causes.

Keywords:
Drug induced acute pancreatitisIdiopathic acute pancreatitis

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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Last Updated: Apr 20, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Area of Science:

  • Gastroenterology
  • Clinical Pharmacology

Background:

  • Acute pancreatitis incidence is rising, necessitating accurate etiological diagnosis for prevention.
  • Idiopathic acute pancreatitis accounts for nearly a quarter of cases, prompting investigation into potential causes like medications.
  • Over-reliance on anecdotal case reports has created confusion regarding drug-induced acute pancreatitis.

Purpose of the Study:

  • To clarify the occurrence and diagnostic challenges of drug-induced acute pancreatitis.
  • To differentiate between true drug-induced cases and misdiagnosed idiopathic pancreatitis.
  • To address misconceptions and improve patient care by emphasizing the rarity of drug-induced acute pancreatitis.

Main Methods:

  • Review of existing literature, including case reports, randomized clinical trials, and pharmacoepidemiologic surveys.
  • Critical evaluation of the quality and reliability of evidence implicating drugs in acute pancreatitis.
  • Analysis of diagnostic criteria for excluding other common etiologies of acute pancreatitis.

Main Results:

  • Drug-induced acute pancreatitis, while possible, is a rare condition.
  • Many reported cases lack rigorous evaluation, leading to overdiagnosis.
  • Misdiagnosis can result in inappropriate treatment and failure to identify underlying idiopathic causes.

Conclusions:

  • Drug-induced acute pancreatitis is uncommon and often overdiagnosed.
  • Accurate etiological diagnosis is crucial to avoid patient harm and litigation.
  • Focus should shift towards identifying the true causes of idiopathic acute pancreatitis.