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[The coleukemogenic action of Bordetella pertussis]
Eksperimental'Naia Onkologiia
|January 1, 1989
Abstract:
Injection of B. pertussis and Rauscher leukemia virus (RLV) in a dose of 4 ID50 to BALB/c mice susceptible to the above virus significantly increases the incidence of leukosis and shortens the average life duration. Injection of B. pertussis to the AKR mice, carriers of the Gross leukosis virus, induces in the first months a greater number of the mice with leukosis and its earlier development.
Insights
Bordetella pertussis (pertussis) infection significantly increases leukosis incidence and mortality in susceptible mice. Pertussis also accelerates leukosis development in mice already carrying a leukemia virus.
Area of Science:
- Immunology
- Virology
- Oncology
Background:
- Bordetella pertussis is a bacterium that causes whooping cough.
- Rauscher leukemia virus (RLV) and Gross leukosis virus are known oncogenic retroviruses.
- The interaction between infectious agents and oncogenic viruses in leukemogenesis is not fully understood.
Purpose of the Study:
- To investigate the effect of Bordetella pertussis (pertussis) infection on leukosis development in mice.
- To determine if pertussis exacerbates existing viral leukemogenesis.
Main Methods:
- BALB/c mice were injected with pertussis and Rauscher leukemia virus (RLV).
- AKR mice, carriers of Gross leukosis virus, were injected with pertussis.
- Leukosis incidence and survival rates were monitored.
Main Results:
- In BALB/c mice, co-injection of pertussis and RLV significantly increased leukosis incidence and reduced lifespan.
- In AKR mice, pertussis injection led to a higher incidence and earlier onset of leukosis within the first few months.
Conclusions:
- Bordetella pertussis infection acts as a potent co-factor in promoting leukosis development.
- Pertussis may accelerate oncogenesis initiated by other viruses, highlighting potential risks in coinfections.