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Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Bone Remodeling and Repair01:31

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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Juvenile Active Ossifying Fibroma.

Brandon R Peterson1, Brenda L Nelson

  • 1Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA, Brandon.peterson2@med.navy.mil.

Head and Neck Pathology
|December 8, 2014
PubMed
Summary
This summary is machine-generated.

This case study details a juvenile active ossifying fibroma in a 27-year-old man. It highlights the key radiologic and histologic features of this rare bone tumor.

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Pathology
  • Radiology

Background:

  • Juvenile active ossifying fibroma (JAOF) is a rare, benign, but locally aggressive fibro-osseous lesion.
  • JAOF typically affects the jawbones, with a predilection for the mandible.
  • Early diagnosis and appropriate management are crucial for favorable outcomes.

Observation:

  • A 27-year-old male presented with symptoms related to a jaw lesion.
  • Radiographic examination revealed a well-defined, expansile lesion with mixed radiodensity.
  • Histopathological analysis confirmed the presence of cellular fibrous tissue with irregular woven bone trabeculae.

Findings:

  • The case presented demonstrates the characteristic imaging findings of JAOF, including its expansile nature and mixed radiolucent-radiopaque appearance.
  • Histologic examination revealed cellular fibrous stroma with osteoblastic rimming and woven bone formation, consistent with active ossification.
  • The lesion exhibited features typical of the juvenile variant, distinguishing it from other ossifying fibromas.

Implications:

  • Accurate radiologic and histologic interpretation is essential for the correct diagnosis of JAOF.
  • Understanding the aggressive potential of JAOF guides surgical planning and follow-up.
  • This case contributes to the literature on JAOF, emphasizing the importance of recognizing its distinct features for optimal patient care.