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Updated: Apr 19, 2026

Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Intravitreal chemotherapy provides control for massive vitreous seeding from retinoblastoma
Abstract:
Treatment of vitreous seeds in retinoblastoma is challenging because of relatively poor chemotherapeutic drug penetration by standard intravenous or intra-arterial routes. Intravitreal monotherapy with melphalan is effective but has a narrow therapeutic window. The authors describe a case of massive vitreous seeding successfully controlled after combination intravitreal chemotherapy using melphalan and topotecan with preserved anatomic outcome.
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