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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Updated: Apr 19, 2026

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

SnapShot: Medulloblastoma.

Jessica M Rusert¹, Xiaochong Wu², Charles G Eberhart³

¹Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

|December 10, 2014

Summary

This summary is machine-generated.

Medulloblastoma, a common childhood brain tumor, is now classified into four subgroups using genomic information. This new classification offers better opportunities for developing successful targeted therapies.

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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

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Published on: October 3, 2010

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

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Published on: November 7, 2015

Area of Science:

Pediatric oncology
Neuro-oncology
Genomics

Background:

Medulloblastoma (MB) is the most frequent malignant pediatric brain tumor.
A significant proportion of patients (one-third) do not survive medulloblastoma.
Current conventional therapies have limited success rates.

Purpose of the Study:

To describe the classification of medulloblastoma subgroups.
To highlight the shift from histopathology-based to genomics-based classification.
To emphasize the potential of genomic classification for targeted therapy development.

Main Methods:

Review of historical histopathology-based classification of MB.
Analysis of current genomics-based classification of MB.
Identification of major MB subgroups based on genomic data.

Main Results:

Genomic information has led to the identification of four major medulloblastoma subgroups.
This classification provides a more precise understanding of MB heterogeneity.
Genomic subgroups offer distinct targets for therapeutic intervention.

Conclusions:

Genomic classification represents a significant advancement in understanding medulloblastoma.
The four major subgroups identified offer improved avenues for developing targeted therapies.
This approach holds promise for improving treatment outcomes in pediatric medulloblastoma patients.