Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

109
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
109
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

152
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
152
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

152
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
152

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fabrication and Characterization of Nerolidol-Based Invasomes: Loading, Stability and Antimicrobial Applications.

Pharmaceutics·2026
Same author

Coaxial Jet Mixing for Pharmaceutical Nanocarrier Production: Experimental Analysis and Mechanistic Modeling.

Pharmaceutics·2026
Same author

Process-guided design of nanoliposomal vitamin D3: formulation, stability and quality by design mapping.

International journal of pharmaceutics·2026
Same author

Improving the Microbiological Safety of Raw Meat Through Visible Blue-Violet Light Irradiation.

Foods (Basel, Switzerland)·2026
Same author

Structural determinants underlying the supramolecular binding between carborane and proteins in water.

Journal of colloid and interface science·2026
Same author

Design of pH‑sensitive alginate-carbopol hydrogel patches for wound healing applications.

International journal of pharmaceutics·2025
Same journal

Dual-Targeted Radionuclide Therapy with <sup>161</sup>Tb Instigates Anticancer Immunity in "Cold" Murine Prostate Tumor.

Molecular pharmaceutics·2026
Same journal

Development of [<sup>111</sup>In]In-CHX-A″-DTPA-αCD68 for ImmunoSPECT to Image Murine Macrophages.

Molecular pharmaceutics·2026
Same journal

Mechanistic Insight into Self-Gelation Involved in Prescription Design for Optimization of Tablet Performance.

Molecular pharmaceutics·2026
Same journal

[<sup>68</sup>Ga]Ga-DOTA-DP-UBI 29-41: A Novel <sup>68</sup>Ga-Labeled Ubiquicidin 29-41 Derivative Containing d-Proline for Bacterial Infection PET Imaging.

Molecular pharmaceutics·2026
Same journal

Comparative Investigation of the Impact of Sodium Citrate Buffers on Lipid Nanoparticles of circRNA or Linear mRNA.

Molecular pharmaceutics·2026
Same journal

Preclinical Evaluation of <sup>177</sup>Lu-Labeled Anti-CLDN18.2 VHH-Fc for Radioimmunotherapy in Gastric Cancer.

Molecular pharmaceutics·2026
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

30.0K

Modeling the drug release from hydrogel-based matrices.

Diego Caccavo1, Sara Cascone, Gaetano Lamberti

  • 1Department of Industrial Engineering and ‡Department of Pharmacy, University of Salerno , via Giovanni Paolo II, 132, 84084 Fisciano, Salerno, Italy.

Molecular Pharmaceutics
|December 16, 2014
PubMed
Summary
This summary is machine-generated.

A new mathematical model accurately describes hydrogel-based oral drug delivery systems. This predictive tool accounts for swelling, erosion, and drug release, aiding in the design of novel pharmaceutical dosage forms.

Keywords:
controlled releasehydrogelsmodelingswellingtransport phenomena

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.5K
A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
08:59

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

19.5K

Related Experiment Videos

Last Updated: Apr 19, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

30.0K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.5K
A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
08:59

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

19.5K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Chemical Engineering

Background:

  • Hydrogel matrices are widely used for oral controlled drug release.
  • Existing models may not fully capture the complex behaviors of these systems.

Purpose of the Study:

  • To develop and validate a mathematical model for hydrogel-based oral drug delivery.
  • To improve predictive capabilities for designing new drug dosage systems.

Main Methods:

  • Mathematical modeling of hydrogel behavior, including water uptake, swelling, drug release, and polymer erosion.
  • Validation of the model using experimental data from hydroxypropyl methylcellulose tablets and theophylline.
  • Refinement of a previous diffusion model by incorporating polymer mass balance to define the erosion front.

Main Results:

  • The model successfully describes water uptake, hydrogel swelling, drug release, and polymer erosion.
  • The improved model reduces the number of fitting parameters compared to previous versions.
  • The model accurately predicts the behavior of the hydrogel-drug system.

Conclusions:

  • The developed mathematical model provides a robust tool for understanding and predicting the performance of hydrogel-based drug delivery systems.
  • This model can significantly aid in the rational design and testing of new oral pharmaceutical dosage forms.