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Vitamin D replacement and type 2 diabetes mellitus
Claire M Issa, Mira S Zantout, Sami T Azar1
1Department of Internal Medicine, Division of Endocrinology and Metabolism, American University of Beirut-Medical Center, 3 Dag Hammarskjold Plaza, 8th floor, New York City, NY 10017, USA. sazar@aub.edu.lb.
Abstract:
The objective of this paper is to review the evidence testing the possible benefit of vitamin D replacement on diabetes control and complications. Type 2 diabetes mellitus (DM 2) has become a significant global health care problem and its reported incidence is increasing at an alarming rate. Despite the improvement in therapy and development of new drugs, treatment is still not optimal especially with the associated adverse effects of most of the available drugs. New efforts are shifted toward disease prevention and a search for safer drugs. New mounting evidence is associating low vitamin D to diabetes mellitus and as such many studies were conducted to test the effect of vitamin D replacement on incidence of diabetes, diabetes control as well as diabetes complications. Although these studies present several limitations, vitamin D replacement seems to have beneficial effect on all aspects of diabetes: incidence, control and complications. Further longer term and more powered controlled trials are necessary to draw firmer conclusions on this beneficial role of vitamin D treatment on DM.
Insights
Vitamin D supplementation may improve type 2 diabetes control and reduce complications. Further research is needed to confirm vitamin D
Area of Science:
- Endocrinology
- Metabolic Diseases
- Nutritional Science
Background:
- Type 2 diabetes mellitus (DM 2) is a growing global health concern.
- Current treatments for DM 2 have limitations and adverse effects.
- Emerging evidence links low vitamin D levels to diabetes.
Purpose of the Study:
- To review existing evidence on vitamin D replacement's effects on diabetes.
- To assess vitamin D's impact on diabetes incidence, control, and complications.
Main Methods:
- Literature review of studies investigating vitamin D and diabetes.
- Analysis of evidence regarding vitamin D's role in diabetes management.
Main Results:
- Vitamin D replacement appears beneficial for diabetes incidence.
- Evidence suggests positive effects on diabetes control.
- Vitamin D supplementation may help manage diabetes complications.
Conclusions:
- Vitamin D replacement shows promise in improving various aspects of type 2 diabetes.
- Further robust, long-term clinical trials are required to solidify these findings.
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