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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
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Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

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Spectrally encoded extended source optical coherence tomography.

Xinyu Liu, Xiaojun Yu, Hongying Tang

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    |December 16, 2014
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    Summary
    This summary is machine-generated.

    We developed a new ophthalmic imaging technique called spectral-encoded extended source optical coherence tomography (SEES-OCT) to boost signal strength. This method enhances imaging depth and sensitivity for better visualization of eye tissues.

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    Area of Science:

    • Ophthalmic imaging
    • Optical coherence tomography
    • Biomedical optics

    Background:

    • Standard optical coherence tomography (OCT) systems face limitations in signal strength and penetration depth for detailed ophthalmic imaging.
    • Improving signal-to-noise ratio is crucial for visualizing deeper ocular structures.

    Purpose of the Study:

    • To introduce and evaluate a novel Spectral-Encoded Extended Source Optical Coherence Tomography (SEES-OCT) technique.
    • To enhance signal strength and penetration depth for ophthalmic imaging applications.

    Main Methods:

    • Development of a SEES-OCT system utilizing a line illumination (7.9 mrad visual angle) generated by a dispersive element.
    • Comparison of the maximum permissible exposure (MPE) between SEES-OCT and standard point-source OCT.
    • Ex vivo imaging of swine eye tissues to demonstrate penetration depth advantages.

    Main Results:

    • SEES-OCT allows for a 3.1 times larger MPE compared to standard point-source OCT.
    • This increased MPE translates to a sensitivity improvement of approximately 5 dB.
    • Demonstrated superior penetration depth in swine eye tissues compared to point-source OCT systems.

    Conclusions:

    • SEES-OCT offers significant improvements in signal strength and sensitivity for ophthalmic imaging.
    • The technique provides enhanced penetration depth, enabling better visualization of ocular structures.
    • SEES-OCT represents a promising advancement for ophthalmic diagnostics and research.