"Nuclear FGF receptor-1 and CREB binding protein: an integrative signaling module"
Michal K Stachowiak1, B Birkaya, J M Aletta
1Department of Pathology and Anatomical Sciences, Western New York Stem Cells Culture and Analysis Center, State University of New York, Buffalo.
Journal of Cellular Physiology
|December 16, 2014
Summary
Fibroblast Growth Factor Receptor-1 (FGFR1) and CREB Binding Protein (CBP) form a nuclear complex regulating genes. This Integrative Nuclear FGFR1 Signaling (INFS) impacts cell differentiation and may be implicated in developmental disorders and cancer.
Area of Science:
- Molecular Biology
- Cell Biology
- Developmental Biology
Background:
- Fibroblast Growth Factor Receptor-1 (FGFR1) traditionally functions at the cell membrane.
- CREB Binding Protein (CBP) is a known transcriptional coactivator.
- Emerging evidence suggests a novel nuclear role for FGFR1 and CBP.
Purpose of the Study:
- To review the current understanding of the novel nuclear regulatory complex formed by FGFR1 and CBP.
- To elucidate the function of Integrative Nuclear FGFR1 Signaling (INFS) in gene regulation and cell differentiation.
- To explore the implications of INFS disruption in disease and its potential therapeutic applications.
Main Methods:
- Review of existing literature on nuclear FGFR1 and CBP interactions.
- Analysis of gene regulation mechanisms involving the FGFR1-CBP complex.
- Discussion of the role of INFS in stem cell and neural progenitor differentiation.
- Examination of INFS involvement in developmental disorders and cancer.
Main Results:
- Nuclear FGFR1 and CBP form a regulatory complex that interacts with and controls numerous genes.
- FGFR1 exhibits dynamic oscillatory interactions with chromatin, mediating gene regulation.
- INFS utilizes a Feed-Forward-And-Gate mechanism to drive stem cell and neural progenitor differentiation.
- Nuclear accumulation of FGFR1 is observed across various cell types.
Conclusions:
- Disruption of INFS is linked to developmental disorders like schizophrenia and metastatic cancers.
- Enhancing INFS could promote cell differentiation for regenerative medicine.
- Targeting INFS may offer strategies to inhibit cancer stem cell proliferation.
More Related Videos
05:44The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo
Published on: April 25, 2016
35.0K
10:52A High-content Imaging Workflow to Study Grb2 Signaling Complexes by Expression Cloning
Published on: October 30, 2012
11.2K
Related Concept Videos
01:16TGF - β Signaling Pathway
11.1K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
11.1K
02:26NF-kB-dependent Signaling Pathway
2.6K
2.6K
02:26NF-κB-dependent Signaling Pathway
10.9K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
10.9K
01:19Interactions Between Signaling Pathways
8.0K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
8.0K
01:45Regulation of Nuclear Protein Sorting
3.5K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
3.5K
01:26Signal Transduction: Overview
13.2K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Typically, signal transduction involves three...
13.2K