[Comorbidities in HIV infection and aging with HIV ]

HIV infection has become a chronic condition with a life-long treatment. As AIDS-related mortality is decreasing, persons living with HIV are aging, their life expectancy tending to reach that of the general population. Aging with the virus and on antiretroviral drugs is raising new challenges: "non AIDS-defining" cancers, cardiovascular diseases, osteoporosis, and maybe neurocognitive disorders represent a new set of comorbidities in this setting, and some of them are now becoming significant causes of death. It is now clear that risk factors for these conditions include the classical risk factors known in the general population, but also risk factors specifically related to the history of HIV infection and its treatment. As a consequence, treating persons with HIV infection now follows two main objectives: controlling the virus and taking long-term comorbidities into account (prevention, testing and treatment). Specificitiesare linked to the existence of HIV-specific risk factors and to the problem of drug-drug interactions with antiretrovirals.