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Updated: Apr 19, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Relationship between periodontitis and systemic diseases: leptin, a new biomarker?
1Department of Pedodontics, Harsarn Dass Dental College, Ghaziabad, Uttar Pradesh, India.
Summary
Leptin may link periodontitis to obesity and cardiovascular disease. Its role in diabetes mellitus type 2 remains unclear, with conflicting evidence on leptin
Area of Science:
- Biomedical Science
- Endocrinology
- Periodontology
Background:
- Leptin, a polypeptide hormone, is implicated in obesity, cardiovascular diseases, and diabetes.
- Periodontitis, an inflammatory condition, is associated with various systemic health issues.
Purpose of the Study:
- To investigate leptin's role as a biomarker connecting periodontitis with obesity, cardiovascular diseases, and diabetes.
- To systematically review existing literature on the association between leptin, periodontitis, and these systemic conditions.
Main Methods:
- Systematic literature search from January 2000 to May 2013 in Cochrane Library and PubMed.
- Inclusion criteria: English-language clinical trials on humans linking leptin and periodontitis to obesity, cardiovascular diseases, or diabetes.
- Keywords used: 'leptin and periodontitis,' 'leptin, periodontitis and obesity,' etc.
Main Results:
- Seven studies met the inclusion criteria from an initial 23.
- Four studies showed a link between leptin, periodontitis, and obesity.
- One study indicated a link between leptin, periodontitis, and cardiovascular diseases; two studies linked leptin, periodontitis, and diabetes mellitus.
Conclusions:
- A positive association exists between serum leptin levels, periodontitis, and systemic diseases like obesity and cardiovascular diseases.
- The relationship between leptin, periodontitis, and type 2 diabetes mellitus is inconclusive, with conflicting findings in the literature.
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