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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Apr 19, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Modeling human lung development and disease using pluripotent stem cells.

Hans-Willem Snoeck¹

¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA Department of Medicine, Columbia University Medical Center, New York, NY, USA Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA hs2680@columbia.edu.

Development (Cambridge, England)

|December 18, 2014

Summary

This summary is machine-generated.

Human pluripotent stem cell (hPSC) differentiation offers a powerful model for studying human development and disease. This approach provides unique advantages over traditional model organisms for understanding complex biological processes.

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Last Updated: Apr 19, 2026

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Published on: April 12, 2021

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Published on: March 23, 2022

Area of Science:

Stem cell biology
Developmental biology
Regenerative medicine

Background:

Human pluripotent stem cells (hPSCs) are crucial for regenerative medicine, disease modeling, and drug discovery.
Directed differentiation of hPSCs offers a unique window into human development, surpassing limitations of model organisms.

Purpose of the Study:

To highlight the significance of hPSC models in understanding human lung development.
To emphasize the utility of hPSC-derived models for studying lung diseases.

Main Methods:

Utilizing directed differentiation protocols for hPSCs.
Employing hPSC models to investigate developmental processes.
Applying hPSC-derived systems for disease modeling.

Main Results:

hPSC differentiation provides a valuable platform for studying human developmental biology.
These models enable detailed investigation of specific organ development, such as the lung.
hPSC models facilitate the study of disease mechanisms and potential therapeutic interventions.

Conclusions:

Directed differentiation of hPSCs is essential for advancing our understanding of human development.
hPSC models offer unparalleled insights into human lung development and associated diseases.
This approach holds significant promise for future regenerative medicine applications.