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[NERVOUS REGULATION OF BILIARY TRACT MOTILITY].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2018
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[SEROTONERGIC REGULATION OF IMMUNITY. PART I].

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Related Experiment Video

Updated: Apr 19, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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[Osteoporosis correction in experiment].

A M Puzikov

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |December 19, 2014
    PubMed
    Summary
    This summary is machine-generated.

    This study simulated osteoporosis in rats using omeprazole and serotonin. Alfacalcidol administration effectively increased bone formation, suggesting a therapeutic benefit for osteoporosis treatment.

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    Area of Science:

    • Biomedical research
    • Pharmacology
    • Bone biology

    Context:

    • Osteoporosis is a significant health concern, often linked to hormonal changes and other chronic conditions like liver fibrosis.
    • Current osteoporosis treatments have limitations, necessitating the exploration of novel therapeutic agents.
    • Experimental models in rats are crucial for investigating disease mechanisms and evaluating potential treatments.

    Purpose:

    • To investigate the effects of alfacalcidol on experimental osteoporosis induced by omeprazole and serotonin in rats.
    • To assess the impact of alfacalcidol on bone metabolism markers in various osteoporosis models.
    • To evaluate the potential of mesenchymal stromal cells in mitigating osteoporosis severity.

    Summary:

    • Osteoporosis was induced in rats via chronic omeprazole or serotonin administration over six months.
    • Bone status was examined in models of liver fibrosis, with and without serotonin administration.
    • Measurements included serum levels of calcium, phosphorus, alkaline phosphatase, albumin, creatinine, and bone mineral content (Ca, P, Mg, Fe).
    • Mesenchymal stromal cells demonstrated a reduction in osteoporosis severity.
    • Alfacalcidol administration, across all experimental groups, led to increased bone formation.

    Impact:

    • This research highlights alfacalcidol as a promising therapeutic agent for enhancing bone formation in osteoporosis.
    • The findings suggest that alfacalcidol could be a valuable addition to osteoporosis management strategies.
    • Understanding the bone-protective effects of alfacalcidol contributes to advancing osteoporosis treatment research.