Related Experiment Video
Updated: Apr 19, 2026
08:04
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
Published on: March 18, 2014
13.4K
Ifosfamide-containing regimens for treating patients with osteosarcomas.
Yan-Yan Li1, Xiao-Ming Jiang, Yi-Guo Dong
1Department of Neurology, The Second People Hospital of Mudanjiang, Mudanjiang, China
Asian Pacific Journal of Cancer Prevention : APJCP
|December 19, 2014
Summary
Ifosfamide-containing regimens show a 44.8% response rate in osteosarcoma treatment. While generally safe, common side effects include neutropenia, leukopenia, and fatigue.
Area of Science:
- Oncology
- Pharmacology
Background:
- Osteosarcoma is a primary bone cancer requiring effective treatment regimens.
- Evaluating ifosfamide-containing regimens is crucial for improving patient outcomes.
Purpose of the Study:
- To systematically analyze the efficacy and safety of ifosfamide-containing regimens in osteosarcoma patients.
- To determine the pooled response rate and identify common adverse events.
Main Methods:
- A systematic literature search identified relevant clinical studies.
- Pooled response rate (RR) and safety data were calculated from eligible studies.
Main Results:
- Four studies with 134 osteosarcoma patients were included.
- The pooled RR for ifosfamide-containing regimens was 44.8%.
- Common adverse effects included neutropenia, leukopenia, and fatigue; no treatment-related deaths were reported.
Conclusions:
- Ifosfamide-containing regimens demonstrate a good response rate and acceptable toxicity for osteosarcoma.
- Further confirmation through randomized clinical trials is recommended.
Related Concept Videos
02:56Treatment Resistant Cancers
3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
02:56Treatment Resistent Cancers
1.5K
1.5K
02:49Cancer Therapies
10.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.9K
02:49Cancer Therapies
3.0K
3.0K
01:25Dosage Regimen: Multiple Oral Dosage
474
Understanding how a drug's concentration fluctuates within the body over time is crucial in pharmacokinetics, particularly with multiple oral doses. A graphical representation of multiple oral dosages provides insight into these dynamics. Typical accumulation curves of a drug's concentration in the body reveal a sawtooth pattern, indicating periodic peaks and troughs correlating with each dose administration and the drug's subsequent elimination.The plasma concentration at any time during an...
474
01:15Drug Dosage Regimen: Overview
4.7K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.7K