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Related Experiment Video

Updated: Apr 19, 2026

Experimental Model of Ligature-Induced Peri-Implantitis in Mice

Experimental Model of Ligature-Induced Peri-Implantitis in Mice

Published on: May 17, 2024

Sequential healing at implants installed immediately into extraction sockets. An experimental study in dogs.

Tomaso Mainetti¹, Niklaus P Lang^2,3, Franco Bengazi¹

¹Faculty of Dentistry, University of Medical Science, La Habana, Cuba.

Clinical Oral Implants Research

|December 19, 2014

Summary

Dental implants placed immediately after tooth extraction show similar osseointegration patterns to those in healed bone. This suggests comparable healing outcomes for immediate implant placement and healed sites without functional loading.

Keywords:

animal study extraction sockets histology implants placed immediately into extraction sockets sequential healing wound healing

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Last Updated: Apr 19, 2026

Experimental Model of Ligature-Induced Peri-Implantitis in Mice

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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

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Published on: January 13, 2023

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair

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Published on: May 23, 2014

Area of Science:

Dental Implantology
Oral Surgery
Histology

Background:

Alveolar bone healing is crucial for dental implant success.
Immediate implant placement into extraction sockets is a common procedure.
Understanding sequential osseointegration is key to optimizing implant outcomes.

Purpose of the Study:

To compare the histological healing process of dental implants placed in healed alveolar bone versus immediately after tooth extraction.
To evaluate new bone apposition and old bone resorption around implants at different time points.
To assess the coronal termination level of osseointegration in both conditions.

Main Methods:

The study utilized a canine mandible model.
Implants were placed in healed molar sites and immediate extraction sockets of premolars.
Histological analysis of biopsies was performed at 1 week, 2 weeks, 1 month, and 3 months post-surgery.

Main Results:

New bone apposition was slightly higher in healed sites (7.4%) versus immediate placement (4.1%) at 1 week, becoming similar by 3 months (67.3% vs 65.3%).
Old bone resorption decreased significantly over time in both groups, reaching minimal levels by 3 months.
The coronal termination level of osseointegration differed at 1 week but was comparable between groups at 3 months.

Conclusions:

Dental implants exhibit similar sequential osseointegration patterns whether placed in healed bone or immediately into extraction sockets.
The initial differences in osseointegration levels and coronal termination resolve by 3 months.
Immediate implant placement without functional load demonstrates comparable healing to implants in pre-healed bone.