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Related Experiment Video

Updated: Apr 19, 2026

Lab-on-a-CD Platform for Generating Multicellular Three-dimensional Spheroids

Lab-on-a-CD Platform for Generating Multicellular Three-dimensional Spheroids

Published on: November 7, 2019

96-well format-based microfluidic platform for parallel interconnection of multiple multicellular spheroids.

Jin-Young Kim¹, David A Fluri², Jens M Kelm²

¹Eidgenössische Technische Hochschule Zürich, Department of Biosystems Science and Engineering, Bio Engineering Laboratory, Basel, Switzerland jinyoung.kim@bsse.ethz.ch.

Journal of Laboratory Automation

|December 20, 2014

Summary

This summary is machine-generated.

This study introduces a novel microfluidic platform for culturing and testing multiple microtissues. This versatile system supports parallel experiments and drug screening in a standard laboratory setting.

Keywords:

automated biology high-throughput screening lab-on-a-chip microfluidics microtechnology

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Area of Science:

Biotechnology
Microfluidics
Tissue Engineering

Background:

Microtissues offer advanced models for drug discovery and disease research.
Current methods for microtissue culture and analysis can be complex and low-throughput.

Purpose of the Study:

To develop a microfluidic platform for parallelized culturing and testing of microtissues.
To enable interconnection of microtissues for continuous perfusion and substance delivery.

Main Methods:

A microfluidic platform compatible with 96-well formats was designed.
The platform accommodates up to 66 microtissues formed via the hanging-drop method.
Primary rat liver and HCT116 tumor microtissues were cultured and treated with 5-fluorouracil.

Main Results:

The platform allows for facile and parallelized culturing of diverse microtissues.
Microtissue interconnection enabled continuous media perfusion and substance dosage.
Successful characterization of the platform using liver and tumor microtissues was achieved.

Conclusions:

The developed microfluidic platform streamlines microtissue handling and experimentation.
This system is suitable for high-throughput drug screening and complex biological assays.
The platform advances the application of microtissues in preclinical research.