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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Retinal vessel caliber changes in vasculitis.

Gerald Liew1, Adnan Tufail, Victoria F Cosatto

  • 1*Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; †Center for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia; ‡Institute of Ophthalmology, University College London, London, United Kingdom; and §Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.

Retina (Philadelphia, Pa.)
|December 20, 2014
PubMed
Summary
This summary is machine-generated.

Retinal vasculitis narrows arterioles but not venules, altering the arteriole-to-venule ratio in affected eyes. This study quantifies in vivo vascular changes in retinal vasculitis.

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Inflammatory Diseases

Background:

  • Retinal vasculitis is an inflammation of retinal vessels that can threaten vision.
  • In vivo vascular changes in retinal vasculitis are not well understood.
  • Quantifying vessel caliber changes is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To measure and compare the caliber of retinal arterioles and venules in eyes with vasculitis versus healthy controls.
  • To investigate the in vivo vascular alterations associated with retinal vasculitis.

Main Methods:

  • A retrospective case-control study design was employed.
  • Fluorescein angiography confirmed retinal vasculitis.
  • Validated semiautomated software was used to measure vessel calibers.

Main Results:

  • Eyes with retinal vasculitis showed significantly narrower arteriolar caliber (143 µm) compared to controls (158 µm) (P=0.01).
  • Venular caliber was similar between vasculitis cases (229 µm) and controls (228 µm) (P=0.91).
  • The arteriole-to-venule ratio was significantly smaller in vasculitis cases (0.63) than in controls (0.70) (P=0.004).

Conclusions:

  • Retinal vasculitis is associated with a reduction in arteriolar caliber.
  • Venular caliber remains unchanged in retinal vasculitis.
  • The observed changes lead to a decreased arteriole-to-venule ratio, indicating significant vascular remodeling in vasculitis.