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Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: a cohort study

Riten Kumar1, Vilmarie Rodriguez2, Jane M S Matsumoto3

  • 1Division of Pediatric Hematology Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.

Thrombosis Research
|December 22, 2014
PubMed

Insights

Post thrombotic syndrome (PTS) affects over 70% of children with deep vein thrombosis (DVT), with moderate-to-severe symptoms in 13%. Predictors include time since DVT and number of affected veins.

Area of Science:

  • Pediatric Medicine
  • Vascular Medicine
  • Thrombosis Research

Background:

  • Post thrombotic syndrome (PTS) is a recognized complication of pediatric deep vein thrombosis (DVT).
  • Limited data exists on identifying predictors for PTS in children.
  • Understanding these predictors is crucial for managing DVT outcomes in pediatric patients.

Purpose of the Study:

  • To identify predictors of post thrombotic syndrome (PTS) in pediatric patients diagnosed with deep vein thrombosis (DVT).
  • To analyze clinical and radiographic factors associated with PTS development after DVT in children.

Main Methods:

  • Retrospective review of pediatric patients (0-18 years) with DVT from 1995-2009.
  • Utilized a validated PTS survey instrument sent to eligible patients.
  • Logistic regression analysis was performed to identify predictors of PTS, calculating odds ratios (OR) and 95% confidence intervals (CI).

Main Results:

  • Ninety pediatric patients participated in the study.
  • 59% reported mild PTS, while 13% reported moderate-to-severe PTS.
  • Independent predictors of PTS included the duration between DVT diagnosis and survey completion (OR 1.75) and the number of thrombosed vein segments (OR 1.40).

Conclusions:

  • Over 70% of children with DVT experience PTS symptoms or signs.
  • Clinically significant moderate-to-severe PTS affects 13% of pediatric DVT patients.
  • The number of thrombosed vein segments and the time elapsed since DVT diagnosis are key predictors of PTS in children.
Abstract

Keywords:
Deep vein thrombosisPost thrombotic syndrome

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