Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Behavior Therapy01:22

Behavior Therapy

1.0K
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
1.0K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.5K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.5K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

238
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
238
Allergic Reactions02:06

Allergic Reactions

34.4K
Overview
34.4K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivities01:30

Hypersensitivities

8.7K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New Structural Insights Into the Potency and Cross-Reactivity of the Major Peanut Allergen Ara h 2.

Allergy·2026
Same author

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract-the B Cell Side.

Allergy·2026
Same author

Convergent monoclonal IgE antibodies from peanut allergic patients are multispecific to immunodominant epitopes of unrelated major peanut and tree nut allergens.

Allergology international : official journal of the Japanese Society of Allergology·2025
Same author

Transcriptomic Profiles of the Nasal Mucosa Following Birch Pollen Provocation Differ Between Birch Pollen-Allergic and Non-Allergic Individuals.

Allergy·2024
Same author

The epithelial barrier theory and its associated diseases.

Allergy·2024
Same author

Modulation of Bronchial Epithelial Barrier Integrity by Low Molecular Weight Components from Birch Pollen.

International journal of molecular sciences·2024
Same journal

Association of Serum Galectin-3 Binding Protein with Acute Exacerbation, Inflammation, and Airway Remodeling in Pediatric Asthma.

International archives of allergy and immunology·2026
Same journal

Effectiveness of a Provincial Law to Improve Epinephrine Use for Anaphylaxis in Schools in Alberta, Canada: A Pre-Post Study.

International archives of allergy and immunology·2026
Same journal

Rab27 a regulates dendritic cell immune tolerogenic capacity.

International archives of allergy and immunology·2026
Same journal

Burden of Hereditary Angioedema in Adults: Impact of Disease and Patient Characteristics.

International archives of allergy and immunology·2026
Same journal

Predictors of Treatment Response to Omalizumab in Children with Chronic Spontaneous Urticaria: A Real World Study.

International archives of allergy and immunology·2026
Same journal

Long-term efficacy beyond 10 years of subcutaneous immunotherapy for house-dust-mite-induced allergic rhinitis: A real-world evidence study.

International archives of allergy and immunology·2026
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

10.0K

Developing therapies for peanut allergy.

Merima Bublin1, Heimo Breiteneder

  • 1Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

International Archives of Allergy and Immunology
|December 23, 2014
PubMed
Summary
This summary is machine-generated.

Peanut allergy immunotherapy is advancing with novel allergen-specific and non-specific approaches. Promising strategies, including modified allergens and immune modulators, aim for effective treatments within ten years.

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

13.0K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.1K

Related Experiment Videos

Last Updated: Apr 19, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

10.0K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

13.0K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.1K

Area of Science:

  • Immunology
  • Allergy Research
  • Food Science

Background:

  • Peanut allergy is a significant global health issue, characterized by IgE-mediated immune responses.
  • Current treatments for peanut allergy are limited, and traditional immunotherapy carries high risks.
  • There is an urgent need for safe and effective peanut allergy immunotherapy.

Purpose of the Study:

  • To review current and emerging immunotherapy strategies for peanut allergy.
  • To explore both allergen-specific and allergen-nonspecific therapeutic approaches.
  • To assess the potential of novel interventions for managing peanut allergy.

Main Methods:

  • Review of preclinical and clinical investigations into various immunotherapy modalities.
  • Examination of allergen-specific methods: subcutaneous, oral, sublingual, epicutaneous immunotherapy, modified allergens, and peptides.
  • Analysis of allergen-nonspecific methods: anti-IgE antibodies, herbal formulations, TLR9 agonists, genetically modified plants, probiotics, and isoflavones.

Main Results:

  • Multiple immunotherapy strategies are under investigation, showing promise for peanut allergy treatment.
  • Allergen-specific approaches include modified peanut allergens and various administration routes.
  • Allergen-nonspecific approaches involve immunomodulatory agents and dietary interventions.

Conclusions:

  • Several promising immunotherapy strategies for peanut allergy are in development.
  • Future treatments may involve individual approaches or combination therapies.
  • Successful immunotherapy for peanut allergy is anticipated within the next decade.