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Updated: Apr 19, 2026
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Construction of the tricyclic core of steenkrotin-type diterpenoids via intramolecular [3 + 2] cycloaddition
Jun Xuan1, Saiyong Pan, Yuanbao Zhang
1Department of Chemistry, Zhejiang University, 148 Tianmushan Road, Hangzhou 310028, China. hfding@zju.edu.cn.
Abstract:
A concise and diastereoselective route to the angularly fused [5-6-7] tricyclic carbon framework of the steenkrotin-type diterpenoids was reported. The key features of the strategy are based on an intramolecular nitrile oxide/alkene [3 + 2] cycloaddition and a regio-selective aldol/dehydration sequence.
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