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Minimal clinically important difference: a novel approach to measure changes in outcome in perioperative medicine

Bernhard Walder1, Julien Maillard, Anne Lübbeke

  • 1From the Division of Anaesthesiology (BW, JM), and Division of Orthopaedic Surgery (AL), Geneva University Hospitals, Geneva, Switzerland.

European Journal of Anaesthesiology
|December 24, 2014
PubMed
Abstract

No abstract available in PubMed .

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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