Related Experiment Video
Updated: Feb 9, 2026

Mating-based Overexpression Library Screening in Yeast
Published on: July 6, 2018
[Chemobiology at happy hour: yeast as a model for pharmacological screening]
Cécile Voisset1, Marc Blondel1
1Inserm UMR 1078 ; Université de Bretagne occidentale, Faculté de médecine et des sciences de la santé ; Établissement français du sang (EFS) ; CHRU Brest, hôpital Morvan, laboratoire de génétique moléculaire, 22, avenue Camille Desmoulins 29200 Brest, France.
Abstract:
Since its discovery and description by Louis Pasteur, the budding yeast Saccharomyces cerevisiae, which was used for thousands of years for alcoholic fermentation and as a leavening agent, has become a popular model system in biology. One of the reasons for this popularity is the strong conservation from yeast to human of most of the pathways controlling cell growth and fate. In addition, at least 30 % of human genes involved in diseases have a functional homolog in yeast. Hence, yeast is now widely used for modelling and deciphering physiopathological mechanisms as well as for developing pharmacological approaches like phenotype-based drug screening. Three examples of such yeast-based chemobiological studies are presented.
Related Concept Videos
Cardiopulmonary Resuscitation IV: Pharmacological Management
Holter Monitor: 24-Hour Monitoring
Yeast Signaling
Cholinergic Antagonists: Pharmacological Actions
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
Drug Abuse and Addiction: Pharmacological Phenomena
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

