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Updated: Apr 19, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
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TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia.
N I Bilous1, I V Abramenko1, A A Chumak1
1SE "National Research Center for Radiation Medicine, National Academy of Medical Sciences of Ukraine", 53 Melnikov Str., Kyiv 04050, Ukraine.
Experimental Oncology
|December 25, 2014
Summary
The TP53 codon 72 polymorphism (rs1042522) is linked to TP53 mutations in chronic lymphocytic leukemia (CLL). The 72Pro/Pro genotype indicates a higher risk of TP53 mutations in treated CLL patients.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- TP53 gene defects are crucial in chronic lymphocytic leukemia (CLL).
- TP53 inactivation correlates with aggressive CLL forms.
- The TP53 codon 72 polymorphism (rs1042522) influences TP53 protein's apoptotic function.
Purpose of the Study:
- To investigate the association between the TP53 codon 72 polymorphism and TP53 mutations in CLL patients.
- To determine if the TP53 codon 72 polymorphism serves as a risk factor for TP53 mutations in CLL.
Main Methods:
- Analysis of 261 CLL samples.
- Polymerase chain reaction and direct sequencing were employed.
- TP53 mutations and single nucleotide polymorphism (SNP) were assessed.
Main Results:
- The 72Pro/Pro genotype was significantly associated with an increased incidence of TP53 mutations.
- This association was observed in previously treated CLL patients (OR = 2.503; p = 0.001).
Conclusions:
- The TP53 codon 72 polymorphism may predict the incidence of TP53 mutations in CLL.
- This polymorphism can be utilized as a risk factor in CLL management.
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