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Pattern selection in growing tubular tissues.

P Ciarletta1, V Balbi2, E Kuhl3

  • 1CNRS and Sorbonne Universités, Université Paris 6, Institut Jean le Rond d'Alembert, UMR 7190, 4 Place Jussieu case 162, 75005 Paris, France and MOX and Fondazione CEN, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.

Physical Review Letters
|December 27, 2014
PubMed
Summary
This summary is machine-generated.

Physical forces like geometry and elasticity regulate tubular organ surface patterns. Changes in layer thickness or stiffness drive transitions from circumferential to longitudinal folds, impacting organ development.

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Area of Science:

  • Biophysics
  • Developmental Biology
  • Tissue Engineering

Background:

  • Tubular organs exhibit diverse surface morphologies crucial for function.
  • The underlying mechanisms regulating these surface patterns are not well understood.
  • Surface morphology is a key clinical indicator for physiological and pathological states.

Purpose of the Study:

  • To investigate the influence of geometry and elasticity on the formation of tubular organ surface patterns.
  • To establish morphological phase diagrams for pattern selection in tubular structures.
  • To elucidate the role of physical forces in organogenesis and surface morphology development.

Main Methods:

  • Computational modeling of tubular structures with varying geometric and elastic properties.
  • Development of morphological phase diagrams to predict pattern selection.
  • Analysis of the relationship between layer thickness/stiffness ratios and resulting surface morphologies.

Main Results:

  • Identified distinct surface patterns including folds, undulations, and protrusions.
  • Demonstrated that increasing thickness or stiffness ratio induces a transition from circumferential to longitudinal folding.
  • Established morphological phase diagrams correlating physical parameters with pattern outcomes.

Conclusions:

  • Physical forces, specifically geometry and elasticity, are critical regulators of tubular organ surface morphology.
  • The findings provide insights into the formation of characteristic structures like esophageal folds and intestinal crypts.
  • This study offers a framework for understanding how physical cues guide organogenesis and tissue patterning.