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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Humoral Immune Responses01:36

Humoral Immune Responses

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Overview
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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Transcytosis of IgG01:15

Transcytosis of IgG

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Common variable immunodeficiency (CVID): new genetic insight and unanswered questions.

Clinical and experimental immunology·2014
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7th International Immunoglobulin Conference: Immunodeficiencies.

Clinical and experimental immunology·2014
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Efficacy and safety of home-based subcutaneous immunoglobulin replacement therapy in paediatric patients with primary immunodeficiencies.

Clinical and experimental immunology·2011
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Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes. A study of 39 patients.

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Immunodeficiencies.

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Subcutaneous immunoglobulin: opportunities and outlook.

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Updated: Apr 19, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

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7th International Immunoglobulin Conference: Immunodeficiencies.

R E Schmidt1, H D Ochs

  • 1Hannover Medical School, Hannover, Germany.

Clinical and Experimental Immunology
|December 30, 2014
PubMed
Summary

Primary immunodeficiency disorders (PID) involve antibody deficiencies treated with immunoglobulin (Ig) replacement therapy. Early diagnosis and individualized treatment plans are crucial for managing PID and secondary immunodeficiency disorders (SID).

Keywords:
diagnosisimmunodeficiencyintravenous immunoglobulinsubcutaneous immunoglobulin

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Area of Science:

  • Immunology
  • Genetics
  • Clinical Medicine

Background:

  • Primary immunodeficiency disorders (PID) often stem from single gene defects, with over 240 identified entities.
  • Antibody deficiencies are a significant subset of PID, necessitating immunoglobulin (Ig) replacement therapy.
  • Secondary immunodeficiency disorders (SID) arise from external factors like immunosuppressive drugs or irradiation.

Purpose of the Study:

  • To review the diagnosis, clinical characteristics, and treatment of PID and SID.
  • To highlight the complexities of Common Variable Immunodeficiency (CVID) and its management.
  • To emphasize the need for research in Ig therapy for various conditions.

Main Methods:

  • Literature review focusing on PID and SID diagnosis and treatment.
  • Discussion of individualized immunoglobulin (Ig) replacement therapy strategies.
  • Examination of Ig therapy applications in autoimmune diseases and post-transplant immunosuppression.

Main Results:

  • PID diagnosis requires early intervention for optimal patient health.
  • Common Variable Immunodeficiency (CVID) presents heterogeneous symptoms and genotypes, demanding tailored treatment.
  • Individualized Ig therapy involves dose adjustment, administration methods, and treatment intervals.

Conclusions:

  • Accurate and timely diagnosis is essential for effective PID management.
  • Individualized treatment plans are critical for patients with Common Variable Immunodeficiency (CVID).
  • Further research is urgently needed for optimizing Ig therapy in diverse immunodeficiency contexts.