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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Development of Immunocompetence01:22

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Humoral Immune Responses01:36

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Overview
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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Transcytosis of IgG01:15

Transcytosis of IgG

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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7th International Immunoglobulin Conference: Immunodeficiencies.

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Common variable immunodeficiency (CVID): new genetic insight and unanswered questions.

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Efficacy and safety of home-based subcutaneous immunoglobulin replacement therapy in paediatric patients with primary immunodeficiencies.

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Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes. A study of 39 patients.

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Updated: Apr 19, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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7th International Immunoglobulin Conference: Immunodeficiencies.

R E Schmidt1, H D Ochs

  • 1Hannover Medical School, Hannover, Germany.

Clinical and Experimental Immunology
|December 30, 2014
PubMed
Summary

Early diagnosis of primary immunodeficiencies (PIDs) through improved screening and individualized therapy, like flexible immunoglobulin administration, enhances patient outcomes. Further research into secondary immunodeficiencies and PID causes is crucial.

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Area of Science:

  • Immunology
  • Clinical Medicine
  • Genetics

Background:

  • Growing awareness of challenges in diagnosing and treating diverse immunodeficiency disorders.
  • Neonatal screening improvements enable earlier diagnosis of primary immunodeficiencies (PIDs).
  • Individualized patient therapy is essential for optimizing clinical outcomes and quality-of-life.

Purpose of the Study:

  • To highlight advancements in PID diagnosis and treatment.
  • To emphasize the importance of personalized therapeutic approaches.
  • To underscore the need for continued research in immunodeficiency disorders.

Main Methods:

  • Review of current diagnostic and therapeutic strategies for PIDs.
  • Discussion of flexible treatment regimens, such as switching immunoglobulin administration routes.
  • Analysis of the role and growth of patient registries.

Main Results:

  • Neonatal screening facilitates early PID detection, enabling timely treatment and complication prevention.
  • Flexible immunoglobulin administration offers adaptable treatment options.
  • Patient registries are expanding, with ~25,000 PIDs patients included, serving as vital research and educational resources.

Conclusions:

  • Early diagnosis and individualized therapy significantly improve outcomes for patients with primary immunodeficiencies.
  • Further research is imperative for optimizing secondary immunodeficiency treatments and understanding PID etiology.
  • Expanding patient registries is critical for advancing research and education in the field of immunodeficiency.