Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

4.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.3K
Epigenetic Regulation01:46

Epigenetic Regulation

34.6K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.6K
Epigenetic Regulation01:46

Epigenetic Regulation

26.7K
26.7K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

39.6K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
39.6K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

8.0K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
8.0K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

10.1K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous sequencing of genetic and epigenetic bases in DNA.

Nature biotechnology·2023
Same author

Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer.

Scientific reports·2022
Same author

Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS).

Journal of cachexia, sarcopenia and muscle·2021
Same author

Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function.

Epigenetics·2021
Same author

Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial.

PLoS medicine·2020
Same author

Applications of machine learning to diagnosis and treatment of neurodegenerative diseases.

Nature reviews. Neurology·2020
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.1K

An epigenetic escape route.

Joanna D Holbrook1

  • 1Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, 117609; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 119228.

Trends in Genetics : TIG
|December 31, 2014
PubMed
Summary
This summary is machine-generated.

Early life environments and genetics shape newborn DNA methylation, influencing future health. These methylation marks may serve as biomarkers for developmental trajectories and potentially offer a way to alter biological fate.

Keywords:
DNA methylationbiomarkerdevelopmental origins of health and disease (DoHAD)epigeneticsgene×environmentnewborn

More Related Videos

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

2.2K
CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

2.9K

Related Experiment Videos

Last Updated: Apr 19, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.1K
In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

2.2K
CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

2.9K

Area of Science:

  • Epigenetics
  • Developmental Biology
  • Genomics

Background:

  • Early life exposures, including the prenatal environment, interact with genetic predispositions.
  • These interactions are increasingly understood through epigenetic mechanisms, particularly DNA methylation.
  • DNA methylation patterns in newborns can reflect gestational conditions and genotype influences.

Purpose of the Study:

  • To explore the role of DNA methylation as a molecular link between early life factors (environment and genetics) and later-life health outcomes.
  • To investigate whether DNA methylation patterns can serve as biomarkers for identifying suboptimal developmental trajectories.
  • To examine the potential of DNA methylation to modify or 'escape' predetermined biological fates.

Main Methods:

  • Analysis of newborn DNA methylomes.
  • Correlating methylation patterns with known genetic factors and documented gestational environmental exposures.
  • Investigating the association between specific methylation marks and health trajectories.

Main Results:

  • Gestational environments leave discernible marks on newborn DNA methylomes.
  • These methylation patterns are often influenced by the individual's genotype.
  • DNA methylation acts as a key molecular mediator connecting early-life influences to health outcomes.

Conclusions:

  • DNA methylation is a critical mechanism linking early-life environment and genetics to health.
  • Methylation marks are valuable potential biomarkers for developmental health.
  • Further research is warranted to determine if DNA methylation can be manipulated to alter health trajectories.