Related Experiment Video
Updated: Apr 19, 2026
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
Published on: December 2, 2016
mAKAP-a master scaffold for cardiac remodeling
Catherine L Passariello1, Jinliang Li, Kimberly Dodge-Kafka
1*Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL; and †Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT.
Signalosomes, like the mAKAPβ complex in cardiac cells, integrate multiple signals to control cellular adaptation. This complex modulates stress-related gene expression, impacting pathological cardiac hypertrophy.
Area of Science:
- Molecular biology
- Cardiovascular research
- Cell signaling
Background:
- Intracellular signal transduction networks regulate cardiac remodeling and cellular adaptation.
- Multimolecular signaling complexes, or signalosomes, are crucial for signal fidelity and pathway crosstalk.
- The protein mAKAPβ acts as a scaffold for a significant signalosome in cardiac myocytes.
Purpose of the Study:
- To investigate the role of the mAKAPβ signalosome in cardiac myocytes.
- To understand how this signalosome integrates various signaling inputs.
- To determine the impact of mAKAPβ signalosomes on stress-related gene expression and cardiac hypertrophy.
Main Methods:
- Studied intracellular signaling pathways in cardiac myocytes.
- Investigated the mAKAPβ protein as a scaffold for signalosomes.
- Analyzed the response of signalosomes to cAMP, calcium, hypoxia, and MAPK signaling.
- Examined the regulation of transcription factors (NFATc, MEF2, HIF-1α) and histone deacetylases.
Main Results:
- The mAKAPβ protein forms a large signalosome in cardiac myocytes.
- This signalosome integrates signals from cAMP, calcium, hypoxia, and MAPK pathways.
- mAKAPβ signalosomes modulate stress-related gene expression.
- These complexes influence the activity of transcription factors and histone deacetylases involved in cardiac hypertrophy.
Conclusions:
- mAKAPβ signalosomes are key regulators of cardiac adaptation and stress responses.
- Signalosome complexes are essential for integrating diverse signaling inputs in cardiac myocytes.
- Targeting mAKAPβ signalosomes may offer therapeutic strategies for pathological cardiac hypertrophy.
