[IgE myeloma. Laboratory typing difficulties]
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Updated: Apr 19, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Nora S Bovone1, María Cristina Fuente, Ana María Gastiazoro
1Servicio de Bioquímica, Laboratorio de Proteínas, Hospital Nacional Alejandro Posadas, Buenos Aires, Argentina.
Abstract:
The IgE multiple myeloma is a rare neoplasm of plasma cell accounting for 0.01% of all plasma cell dyscrasias. They are generally of more aggressive development and to date there are no more than 50 cases published in current literature. Laboratory studies are, in these cases, essential for the classification of the monoclonal component in serum and urine. The aim of this presentation is to report a patient diagnosed with IgE myeloma and to point out that the laboratory difficulties noted in these rare cases can lead to an erroneous report.
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