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Updated: Apr 18, 2026
Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a
Hui-Jing Xiang1, Lu An, Wei-Wei Tang
1Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China. liujingang@ecust.edu.cn.
Abstract:
A multifunctional nitric oxide (NO) delivery nanoplatform that combines functionalities of target directing, fluorescence tracking, and photo-controlled target attacking was developed. The {Ru-NO@TiO2 NPs} nanoplatform selectively targeted folate-receptor over-expressed cancer cells while being simultaneously traced based on its inherent fluorescence. Intracellular localized NO and singlet oxygen were produced on demand by controlled visible light illumination, producing a synergistic cytotoxic effect to cancer cells.
