Multi-scale approach for simulating time-delay biochemical reaction systems
Yuanling Niu1, Kevin Burrage2, Chengjian Zhang3
1Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People's Republic of China. yuanlingniu@gmail.com.
Abstract:
This study presents a multi-scale approach for simulating time-delay biochemical reaction systems when there are wide ranges of molecular numbers. The authors construct a new efficient approach based on partitioning into slow and fast subsets in conjunction with predictor-corrector methods. This multi-scale approach is shown to be much more efficient than existing methods such as the delay stochastic simulation algorithm and the modified next reaction method. Numerical testing on several important problems in systems biology confirms the accuracy and computational efficiency of this approach.
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