A multi-pair electrode based impedance sensing biopsy needle for tissue discrimination during biopsy process

Area of Science:

• Biomedical Engineering
• Medical Devices
• Biosensing Technology

Background:

• Accurate biological tissue discrimination is crucial for effective biopsies.
• Existing biopsy methods may lack real-time tissue analysis capabilities.
• Developing integrated sensing devices can enhance diagnostic precision.

Purpose of the Study:

• To demonstrate a novel biopsy needle integrated with a multi-pair electrode impedance sensing device.
• To evaluate the device's capability for selective tissue analysis during the biopsy process.
• To validate the device's effectiveness in biological tissue discrimination.

Main Methods:

• Integration of multi-pair electrodes into a biopsy needle for impedance sensing.
• Conductance measurements of various saline solutions to calibrate the device.
• Real-time conductance monitoring of soft elastomeric materials during needle insertion.
• In-situ tissue discrimination of porcine meat tissues using the impedance sensing biopsy needle.

Main Results:

• The impedance sensing biopsy needle demonstrated selective tissue analysis capabilities.
• Successful conductance measurements and real-time monitoring of materials were achieved.
• The device successfully discriminated between different porcine meat tissues during needle insertion.

Conclusions:

• The impedance sensing biopsy needle with multi-pair electrodes is a viable tool for biological tissue discrimination.
• The integrated device offers potential for enhanced accuracy and selectivity in biopsy procedures.
• This technology shows promise for improving diagnostic outcomes in clinical settings.