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Updated: Apr 18, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Nootropic dipeptide noopept enhances inhibitory synaptic transmission in the hippocampus
I S Povarov1, R V Kondratenko, V I Derevyagin
1Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia, povarovigor@mail.ru.
Abstract:
Application of nootropic agent Noopept on hippocampal slices from Wistar rats enhanced the inhibitory component of total current induced by stimulation of Shaffer collaterals in CA1 pyramidal neurons, but did not affect the excitatory component. A direct correlation between the increase in the amplitude of inhibitory current and agent concentration was found. The substance did not affect the release of inhibitory transmitters from terminals in the pyramidal neurons, which indicated changes in GABAergic interneurons.
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