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Updated: Apr 18, 2026
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
[Abscopal effect in the treatment of malignant melanoma]
C Thallinger1, G Prager, H Ringl
1Klinische Abteilung für Onkologie, Comprehensive Cancer Center, Universitätsklinik für Innere Medizin I, AKH Wien, Medizinische Universität Wien, Währingergürtel 18-20, 1090, Wien, Österreich, Christiane.Thallinger@meduniwien.ac.at.
Background:
The clearance of non-irradiated tumors after localized radiation therapy is known as the abscopal effect.
Case Report:
In the present case report we initiated a combined therapeutic approach based on sequential administration of ipilimumab plus temozolomide in combination with radiotherapy. The treatment regime was well tolerated and resulted in unusually long disease stabilization and in a complete response of brain and kidney metastases. Thus, it is speculated that the clinical response was the result of an abscopal effect.
Conclusion:
The present case report highlights the possible clinical benefit of the abscopal effect in the treatment of malignant melanoma.
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