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The ViennaRNA web services.

Andreas R Gruber1, Stephan H Bernhart, Ronny Lorenz

  • 1Biozentrum, University of Basel, Klingelbergstrasse 50-70, 4056, Basel, Switzerland, agruber@tbi.univie.ac.at.

Methods in Molecular Biology (Clifton, N.J.)
|January 12, 2015
PubMed
Summary
This summary is machine-generated.

The ViennaRNA web services offer user-friendly online tools for predicting RNA secondary structures and detecting noncoding RNAs. These services provide access to advanced functionalities for RNA folding kinetics and sequence design.

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Area of Science:

  • Computational Biology
  • Bioinformatics
  • Molecular Biology

Background:

  • The ViennaRNA package is a foundational software suite for thermodynamic RNA secondary structure prediction.
  • Numerous extensions have been developed to address specific challenges like noncoding RNA detection, RNA folding kinetics, and RNA-RNA hybridization-aware sequence design.

Purpose of the Study:

  • To introduce and describe the ViennaRNA web services, providing accessible online access to the package's core and extended functionalities.
  • To guide users on performing key tasks including minimum free energy structure prediction, RNA-RNA hybrid prediction, and noncoding RNA detection.

Main Methods:

  • Utilizing the ViennaRNA package's core algorithms and extended tools through a web-based interface.
  • Providing a user-friendly platform for executing complex RNA structure and function analyses without local software installation.

Main Results:

  • The ViennaRNA web services offer free and easy access to a comprehensive suite of RNA analysis tools.
  • Users can perform diverse tasks such as predicting minimum free energy structures, RNA-RNA interactions, and identifying noncoding RNAs.

Conclusions:

  • The ViennaRNA web services democratize access to powerful RNA bioinformatics tools.
  • The online platform facilitates research in RNA structure, function, and design for a broader scientific community.